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The direct and indirect pathways originate from different subsets of striatal medium spiny cells: They are tightly intermingled. All these brain regions are interconnected with SN: they receive dopamine innervation and send back direct or indirect projections that can. The substantia nigra (SN) is a midbrain dopaminergic nucleus which has a on multiple neuronal populations throughout the basal ganglia. Various enzymes are released from the nigro-striatal pathway. The hypothesis that these enzymes--i.e., acetylcholinesterase, nonspecific cholinesterase. These neurons are medium-sized to large, fusiform, and frequently elongated; they have several large radiating dendrites. The axon emerges from the cell body or. Substantia Gelatinosa (Lamina II). The substantia gelatinosa contains numerous cell types. Many cells are local interneurons and likely play an important role. Various Artists - Substantia - Music. Substantia. Import. Various Artists (Artist) Format: Audio CD. See all formats and editions Hide other. Apoptosis of dopaminergic neurons in the SNc affects all BG nuclei. Dopamine influences information integration by the SNr in various ways. SNc. An area that is functionally analogous to the substantia nigra pars compacta is the A number of intrinsic pathways interconnect various basal ganglia. The differential diagnosis of Parkinson's disease (PD) and multiple system atrophy (MSA) remains a challenge, especially in the early stage.